You are designing a randomized clinical trial of a new anti-hypertensive medication.

You are designing a randomized clinical trial of a new anti-hypertensive medication. The goal is to lower the incidence of stroke, but a surrogate endpoint will be used instead of stroke as the primary endpoint of the trial.

(1) Give an example of a surrogate endpoint that makes sense for the context of this clinical trial.

(2) In the context of this trial, give a rationale for why an investigator might decide to use a surrogate endpoint.

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A surrogate endpoint of a clinical trial would be a laboratory value or biomarker used as a substitute for a clinically meaningful endpoint. The clinically meaningful endpoint measures directly how a patient feels, fun…

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